OBJECTIVE OF THE SEPARATION
Peter Schoenmakers
,
University of Amsterdam
,
Netherlands
Abstract
This chapter has been written by Peter Schoenmakers, Stella Brudin and Peter Pruim.
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Improving the separation
How to manipulate a separation
Parameters that affect separation
Normal-phase liquid chromatography
Reversed-phase liquid chromatography
Ion exchange chromatography
Ion pairing (ion interaction) chromatography
Improving the separation
Simplifying the separation
Optimization of isocratic separations
Optimisation of gradient elution
PRACTICAL MOBILE PHASE OPTIMIZATION
SYSTEM OPTIMIZATION
OBJECTIVE OF THE SEPARATION
> OVERVIEW OF OPTIMIZATION CRITERIA
> MULTI-CRITERIA DECISION MAKING
> DEVELOPMENT OF ROBUST METHODS
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