Abstract Ionization is the process whereby neutral molecules are converted into charged species (i.e. ions). The conventional electron ionization technique can only be used for low to moderate molecular weight volatile compounds, while soft ionization techniques are suitable for the ionization of a wide range of molecules, regardless of their polarity, molecular weights, and are capable of creating both positively or negatively charged ions. Soft ionization techniques, especially atmospheric pressure ionization techniques (ESI, APCI and APPI), are well suited for HPLC/MS coupling.
KeywordsIonization, Molecular ion, Fragmentation, Electron ionization, Electrospray ionization, Atmospheric pressure chemical ionization, Atmospheric pressure photoionization, Matrix-assisted laser desorption/ionization
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