Abstract The historical trend among column packings has been towards smaller and more regularly shaped particles. Regular particle shape improves the uniformity of the packed column bed. Decreased particle size improves the efficiency (N) of a column, though there are also other important considerations when selecting a column. Resolution increases with the square root of N. Thus, decreased particle size can increase resolution, but at the expense of increased backpressure, the risk of more frequent column blockage, and increased difficulty of column manufacture.
KeywordsMiniaturization, Efficiency, van Deemter equation, A-term, Cm-term, Cs-term, Particle size, Particle shape, Packing, Analysis time, Solvent consumption, Plate number, Resolution, Darcy’s law, Pressure drop, Backpressure, Blockage.
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