Multidimensional LC

Tuulia Hyotylainen, VTT Technical Research Centre of Finland, Finland

Abstract Many samples contain such a large amount of compounds that a single chromatographic separation does not provide sufficient separation efficiency. In such cases the separation power can be enhanced by using a multidimensional chromatographic technique. 2-dimensional LC can be divided into two categories, namely in heart-cut (LC-LC) and comprehensive techniques(LCxLC).

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Topic owner

Tuulia Hyotylainen

Multidimensional LC methods allow efficient analysis of complex samples and offer higher separation power than conventional LC. If a mass spectrometer is used as detector, the efficient separation also minimises problems with ion suppression.
This Topic currently covers the instrumentation required for the multidimensional LC and the parameters for on-line coupling. We are preparing a number of chapters e.g. applications in food and environmental analysis. Your input is welcome.