LC Detectors, general aspects

Abstract Universal detectors detect any compound via the bulk properties of its solution, while specific detectors respond to physical or chemical properties of the sample compound. The detector’s limits (Limit of detection, limit of identification and limit of quantitation) are a function of both detector sensitivity and detector noise, and are defined as the quantities of analyte that generate a signal that is a given factor higher than the standard deviation of the blank signal (i.e. the noise). Other figures of merit, including detector dead volume and linear dynamic range should be considered in choosing a detector.

KeywordsDetector, Universal detector, Specific detector, Analyte, noise level (ND), Detector response factor (R), Linear dynamic range (DL), Instrumental sensitivity (S), Instrumental peak broadening (sd), Noise, Spikes, Wander, Drift, Filter, Limit of detection (LOD), Limit of identification (LOI), Limit of quantitation (LOQ), Time constant, Peak broadening


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